What is the route of administration for the epinephrine auto-injector in anaphylaxis?

What is the route of administration for the epinephrine auto-injector in anaphylaxis?

• A. Intravenous
• B. Intramuscular
• C. Sublingual
• D. Intraosseous

Answer: (B)

The epinephrine auto-injector is given intramuscularly, into the mid-outer thigh. This route is chosen because muscle tissue allows rapid, reliable absorption of epinephrine, which is critical in anaphylaxis to quickly reverse airway swelling, bronchoconstriction, and low blood pressure. Subcutaneous absorption can be slower and less predictable, especially when circulation is compromised during anaphylaxis, making it less effective. Intravenous administration is only used in controlled hospital settings under supervision due to higher risk and need for monitoring, while sublingual and intraosseous routes are not appropriate for delivering the auto-injected dose.

The epinephrine auto-injector is given intramuscularly, into the mid-outer thigh. This route is chosen because muscle tissue allows rapid, reliable absorption of epinephrine, which is critical in anaphylaxis to quickly reverse airway swelling, bronchoconstriction, and low blood pressure. Subcutaneous absorption can be slower and less predictable, especially when circulation is compromised during anaphylaxis, making it less effective. Intravenous administration is only used in controlled hospital settings under supervision due to higher risk and need for monitoring, while sublingual and intraosseous routes are not appropriate for delivering the auto-injected dose.